Semax Research

Semax 10 mg is supplied by Healthy Peps as a lyophilized synthetic heptapeptide for neuropeptide research, shipped from Canada with batch documentation and an available COA.

Physicochemical Reference Data

Mechanism & Research Context

Semax is a synthetic heptapeptide developed from the ACTH(4-10) fragment with a C-terminal Pro-Gly-Pro extension that increases stability against peptidase degradation. In the research literature it is studied as a neuropeptide with reported effects on BDNF and NGF expression in cell and animal models, which is the mechanism most neuropeptide laboratories cite when using it.

The compound has an unusually deep preclinical literature relative to most research peptides, largely from Russian research groups, spanning ischaemia models, oxidative-stress studies and cognitive-behavioural endpoints in rodents. Published reports describe investigation in ischaemic stroke settings, which is why Semax appears in neurological research reviews far more often than in other application areas.

For laboratory work, Semax is used in neurotrophic-factor expression assays, neuronal culture studies and neuroprotection models. Its peptide nature means analytical verification by HPLC is straightforward, and the batch documentation reports a single-peak purity result.

The 10 mg format covers a substantial number of in vitro experiments while remaining a single documented batch.

How It Compares to Related Peptides

Semax belongs to the neuropeptide family, not the GH-axis or incretin families. Its nearest catalogue relative by origin is Selank — both are short synthetic neuropeptides developed in the same research tradition — but they derive from different parent sequences and are studied against different endpoints, so they are complementary rather than interchangeable.

Reconstitution, Stability & Handling

Reconstitute with bacteriostatic water, adding it against the vial wall and swirling gently — avoid vortexing. Store reconstituted solution refrigerated and use within your protocol window. Lyophilized vials should be held at −20 °C, protected from light and moisture.

Selected Reading & Research Notes

• Russian preclinical and clinical Semax literature. Reports on the ACTH(4-10) analog in ischaemia models, neurotrophic-factor expression studies and cognitive endpoints.
• Neuropeptide stability research. Describes the Pro-Gly-Pro extension as a peptidase-resistance modification relative to the parent ACTH(4-10) fragment.

Frequently Asked Questions